Symptoms of deep vein thrombosis (DVT) typically consist of unilateral leg swelling, redness, pain and discomfort, and are usually of acute onset. However, symptoms are variable and can be minimal in up to 50% of patients. The symptoms and signs are non-specific, and only a third of patients with a clinical suspicion of DVT have the condition. A thorough history and careful examination will help rule out other causes. Patients with suspected DVT should have a Wells score performed in combination with a D-dimer assay.