GPs have concerns about prescribing strong opioids for chronic non-cancer pain (CNCP), a qualitative study has shown. The issue most cited was the potential for development of tolerance and dependence. Seventeen GPs from the South West of England were interviewed individually about their current prescribing practices using semi-structured interviews. Information was supplemented through a focus group meeting involving another five GPs. Transcripts of the interviews and focus group were analysed by thematic analysis.