Sometimes the effect of prolonged and lavish use of chloroform on the class of subjects to whom we have just referred is even more mischievous. It has been known to take the form, especially in women who are at or near the menopause, of violent erotic excitement, to which no doubt there was a tendency resulting from the physiological state, but which was definitely aggravated by the injudicious use of chloroform; the proof being that it diminished, or even practically ceased immediately that the drug was discontinued.