I have reported cases in The Practitioner of several old persons who have died while labouring under senile delirium, all of which were attended by excessive talking that would continue hour after hour, and day after day, exhausting themselves such that they effectually talked themselves to death. It occurred to me to consider whether the cerebral symptoms of senile delirium could be traceable to a derangement of liver function. I had not long to wait before testing the value of this idea on a case. I confess to having some anxiety as to the result.