Mrs A. was a stout lady, about 45, who was the mother of a family of twenty, all alive. Her husband had met with some business reverses, and they had to give up their house in London. She stated her present condition came on gradually until she lost power of her lower extremities. In reply to my question, if there and then taken out of bed what did she think would happen, she said if she attempted to stand, her legs would give way and she would collapse on the floor. In every other way she was healthy. On examination, there was no atrophy or rigidity of the muscles; the knee-jerks, though faint, were present. Sensation was, as well as I can remember, not affected.